ASSESSMENT OF INSULIN RESISTANCE AND SENSITIVITY BY HOMA–IR AND QUICKI IN PATIENT WITH METABOLIC SYNDROME & TYPE–2 DIABETES MELLITUS

Dabir Shakib; Badade ZG; Yadav Shashi RM

Volume : VI, Issue : IV, April - 2016

ASSESSMENT OF INSULIN RESISTANCE AND SENSITIVITY BY HOMA–IR AND QUICKI IN PATIENT WITH METABOLIC SYNDROME & TYPE–2 DIABETES MELLITUS

Dabir Shakib, Badade Zg, Yadav Shashi Rm

Abstract :

Insulin Resistance (IR) is a condition in which the body produces insulin but does not use it effectively. When people have insulin resistance, glucose rises in the blood instead of being absorbed by the cells, leading to type–2 diabetes or pre–diabetes. Insulin resistance is an assurance of metabolic syndrome. It is important to identify Insulin resistance as it is early stage before development of diabetes mellitus (Type–2). Insulin sensitivity is inverse of insulin resistance. The standard method to measure Insulin resistance is Homeostasis Model Assessment of Insulin Resistance (HOMA–IR) and for Insulin sensitivity it is Quantitative Insulin Sensitivity Check Index (QUICKI). Therefore present study is to assess insulin resistance and sensitivity by HOMA–IR and QUICKI. OBJECTIVES: The aim of the present study is to assess insulin resistance and sensitivity by HOMA–IR and QUICKI in patients with Metabolic Syndrome and Type–2 Diabetes Mellitus. MATERIALS AND METHODS: Total 120 volunteers were enrolled in present study, carried out in the Department of Biochemistry and Department of General Medicine, MGM Medical College, Navi Mumbai. Total 120 volunteers were divided into three groups. Group–I included 40 metabolic syndrome patients as per NCEP ATP III criteria. Group–II included 40 Type–2 Diabetes mellitus patients as per WHO criteria and Group–III included 40 healthy individuals. BMI, Waist/Hip ratio of subjects were calculated. Blood samples were collected from vein under condition of 12 hours of fasting. Triglyceride and High density lipoprotein levels were also estimated in all subjects. RESULTS: The significant difference was observed in BMI, Waist/Hip ratio, TG and HDL in control and study groups (p≤0.001). The scatter diagram of HOMA–IR and QUICKI shows negative correlation in patients with metabolic syndrome. (r = –0.918, p ≤ 0.0001) and also with Type–2 Diabetes mellitus (r = –0.949, p ≤ 0.0001). CONCLUSION: Present study shows reciprocal relationship between HOMA–IR and QUICKI in metabolic syndrome and type–2 diabetes mellitus.