Assessment of p53 at codon 72 polymorphism in Breast Cancer patients from King George Hospital, Visakhapatnam

Dr. P. Sudha Padmasri; Swarupa R Didla

Volume : VIII, Issue : I, January - 2018

Assessment of p53 at codon 72 polymorphism in Breast Cancer patients from King George Hospital, Visakhapatnam

Dr. P. Sudha Padmasri, Swarupa R Didla

Abstract :

The p53 is a tumor suppressor gene and plays an important role in the etiology of east cancer. p53 tumor suppressor gene frequently is mutated in many forms of human carcinomas. Studies have produced conflicting results concerning the role of p53 codon 72 polymorphism (G>C) on the risk of east cancer; therefore, a meta–analysis was performed to estimate the association between the p53 codon 72 polymorphism and east cancer. Breast cancer is among cancers with high prevalence and is the second most common cancer in women around the world. Thirty percent of all cancers and 15% of cancers– caused deaths among women are due to this cancer. According to the report of World Health Organization in Feuary 2009, the annual east cancer death rate is 519 thousand people worldwide. We tested the hypothesis that the Pro/Pro genotype is associated with increased east cancer risk in a case–control study of east cancer that included 98 cases and 100 controls. Samples were obtained from Department of Gynaecology and Obstetrics , King George Hospital and Padmasri Clinic, Visakhapatnam from January 2016 to November 2017. The DNA was isolated by a simple, rapid, non–enzymatic method. In the current study of 98 east cancer patients, we found that the patients with p53Arg/Pro heterozygotes or the combined p53 Arg/Pro heterozygotes (58%) with Pro/Pro (17%) homozygotes had a significantly increased risk of malignancy. It is likely that the different functions of Arg allele and Pro allele affect DNA repair capacity, apoptosis, and chromosome sensitivity to mutagens, and consequently influence risk of cancer. The p53 gene may modulate the response to environment carcinogens and thereby affect the risk of developing east cancer.