ASSESSMENT OF SEVERITY OF ORGANOPHOSPHORUS POISONING AND PREDICTING THE NEED FOR VENTILATORY SUPPORT.

Dr .Uma.M.A.; Dr.Nagakiran.K.V; Dr. Rakesh Koppulu

Volume : VIII, Issue : II, February - 2018

ASSESSMENT OF SEVERITY OF ORGANOPHOSPHORUS POISONING AND PREDICTING THE NEED FOR VENTILATORY SUPPORT.

Dr . Uma. M. A. , Dr. Nagakiran. K. V, Dr. Rakesh Koppulu

Abstract :

INTRODUCTION:

Respiratory failure is the one of the major complication leading to death in organophosphorus compound poisoning . Early recognition of respiratory failure and prompt ventilatory support may improve survival in these patients.

Aim of study: This study was undertaken to assess the severity of organophosphorus(OP) compound poisoning both clinically by using Peradeniya scoring, estimating seum cholinesterase levels and to correlate serum cholinesterase levels and Peradeniya OP poisoning scale to predict the need for ventilatory support.

Materials and methods: prospective descriptive and intention to treat study conducted at Narayana medical college for one year period. 149 patients were included in study after applying inclusion and exclusion criteria. Serum cholinesterase levels and Peradeniya organophosphorus compound poisoning (POP)score were studied in all cases.

Result: Most of patients with moderate (65%) and severe poisoning (100%) according to POP scale required ventilatory support. Most of patients with moderate (40%) and severe poisoning (100%) according to POP scale expired. P value <0.005. 85% of patients with PChe levels <50% required ventilatory support. Patients with PChe levels <50% had more mortality compared to patients with PChe levels >50%.

Conclusion: POP score of more than 5 correlated in predicting the need for ventilatory support and mortality. Pseudo cholinesterase levels in conjuction with Peradeniya OP poisoning score is a useful parameter for grading severity of OP poisoning and in predicting the need for ventilatory support and mortality.