Assessment of small, dense low density lipoprotein cholesterol as a marker of cardiovascular risk in Indian patients with type 2 diabetes mellitus

Namrata. B. Kulkarni; Meghana.U. Ganu; Sanjay. G. Godbole; Sudha.S. Deo

Volume : V, Issue : II, February - 2015

Assessment of small, dense low density lipoprotein cholesterol as a marker of cardiovascular risk in Indian patients with type 2 diabetes mellitus

Namrata. B. Kulkarni, Meghana. U. Ganu, Sanjay. G. Godbole, Sudha. S. Deo

Abstract :

Aims the present study was conducted to asses sdLDL–C and Oxidized LDL (oxLDL–C) levels in patients with T2DM in comparison to hypertensive and healthy controls, and their correlation with Framingham risk score (FRS). Study Population The study population consisted of patients with T2DM (>5 years) along with hypertension (n=55), newly detected patients with T2DM (<2 years) without hypertension (n=28), patients with hypertension (n=31) and healthy controls (n=30). Results Serum levels of sdLDL–C and oxLDL–C were significantly higher in patients with T2DM compared to hypertensive and healthy controls. (All P<0.001).sdLDL–C also showed a strong correlation with FRS and HbA1c in the total study population. (P<0.001) Conclusions sdLDL–C levels were increased in patients with diabetes indicating high risk of developing subclinical atherosclerosis. In addition, a strong correlation between sdLDL–C and FRS suggests that sdLDL–C may contribute significantly to the excess risk of CVD in patients with T2DM.