Assessment of vitamin D levels and other Inflammatory Markers in Obese and Non–Obese Patients with Polycystic Ovary Syndrome

Dr. P. Srinivas Rao; Dr. D. Vijayasekhar Reddy; Dr. Deepika M.L.N

Volume : VII, Issue : X, October - 2017

Assessment of vitamin D levels and other Inflammatory Markers in Obese and Non–Obese Patients with Polycystic Ovary Syndrome

Dr. P. Srinivas Rao, Dr. D. Vijayasekhar Reddy, Dr. Deepika M. L. N

Abstract :

The clinical features of PCOS are often associated with obesity and chronic inflammation; it was aimed to assess vitamin D levels along with other inflammatory markers in PCOS women.

A total of 200 subjects were collected from Cytomol Labs and various endocrine clinics. Three milliliter blood samples were obtained and used for estimation of Vitamin D. For cases deficient in vitamin D, hS C–reactive protein (hsCRP), interleukin 6 (IL–6) and tumor necrosis factor alpha (TNF–α) levels were estimated using standard kits.

The vitamin D deficiency was observed in 76% of cases with a mean level of 12.7 ± 0.89. Estimation of hsCRP, TNF–α and IL6 in vitamin D deficient cases and also in obese and non–obese groups demonstrated difference suggesting the involvement of vitamin D and other markers in the aetiopathogeneis of PCOS. Hence, treatment with vitamin D, calcium supplementation in addition to metformin could be beneficial in managing PCOS.