Assessment the immunohistochemical expression of Galectin–3 in Iraqi patients with colorectal carcinoma.

Ban Jasim Mohamad; Khawla Hoori Zghair; Faeza Aftan Zghair

Volume : V, Issue : IX, September - 2015

Assessment the immunohistochemical expression of Galectin–3 in Iraqi patients with colorectal carcinoma.

Ban Jasim Mohamad, Khawla Hoori Zghair, Faeza Aftan Zghair

Abstract :

In the current study hundred ten of Iraqi patients with colorectal tumors were studied to evaluate the expression of Galectin–3 using Tissue microarray–Immunohistochemisty (TMA–IHC) technique. Of them, Ninety cases had colorectal carcinoma, and twenty had benign tumors. A group of twenty cases of non–specific colitis and other twenty colonic biopsies with no significant pathology were also studied. Results revealed that Galectin3 expression was positive in 66.7% of malignant cases. With significant correlation (P=0.04) with tumor grade, compared with adenoma cases in which 10% of them showed positive expression of galectin–3.