Volume : IX, Issue : VI, June - 2019

Associated Syndromes In Cleft Lip Palate And Isolated Cleft Palate Babies: A Retrospective Study In Cyprus

Beste Kamiloglu

Abstract :

Introduction: Whilst clefts of the lip with or without cleft palate (CLP) are most common birth defects among facial clefts, clefts of the palate(CP) are the rarest form of oral clefts. Nevertheless, both facial cleft types are increasing numerically among different populations all over the world. 50% of isolated clefts may be as part of a syndrome while 50% may only be isolated, non–syndromic cleft. The etiologies of both cleft lip palate and isolated cleft palate are still unknown, but both are multifactorial involving genetic and environmental risk factors. Accurate estimates of population frequency are difficult to obtain because of variations in reliability of reporting and the tendency to combine or mislabel cases of CLP and CP. Inclusion of stillbirths may complicate the situation even further. Materials and Method: At this study, among a total of 27 cleft lip palate and isolated cleft palate babies born between years 2007–2017 in Northern Cyprus (a small Mediterranean Island), syndromic cases were detected. Later, types of syndromes were identified. Results: Evaluation among 27 oral clefting babies, unilateral or bilateral cleft lip palate distribution was 18, while isolated cleft palate was 9. A total of 6 syndromic cleft cases were detected among which 5 of them were boys and only 1 girl was syndromic which contributes to a ratio of 20:1 males to females. Syndromes detected could be listed as; Pierre Robin Sequence, Treacher Collins Syndrome, Velo–cardio–facial Syndrome, Microlissencephaly and Charge Syndrome. Conclusion: The etiology of cleft lip palate and isolated cleft palate are not fully known and several infants with oral clefts are born at different rates in different populations.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

ASSOCIATED SYNDROMES IN CLEFT LIP PALATE AND ISOLATED CLEFT PALATE BABIES: A RETROSPECTIVE STUDY IN CYPRUS, Beste Kamiloglu INDIAN JOURNAL OF APPLIED RESEARCH : Volume-9 | Issue-6 | June-2019

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