Association between APO E4 and Abdominal Aortic Atherosclerosis among Elderly Diabetic Patients

Dr. Moatasem Salah Amer; Dr. Randa Reda Mabrouk; Dr. Hala Samir Sweed; Dr. Nesrine Aly Mohamed; Dr. Sherine Mohamed Ibrahim Sharara; Hanaa Farag Bekhet Awad

Volume : V, Issue : XI, November - 2015

Association between APO E4 and Abdominal Aortic Atherosclerosis among Elderly Diabetic Patients

Dr. Moatasem Salah Amer, Dr. Randa Reda Mabrouk, Dr. Hala Samir Sweed, Dr. Nesrine Aly Mohamed, Dr. Sherine Mohamed Ibrahim Sharara, Hanaa Farag Bekhet Awad

Abstract :

<p>&nbsp;Objective: This study assessed the association between APO E4 gene and abdominal aortic atherosclerosis among Elderly Diabetic Patients. Method: A Case control study, Ninety elderly patients were recruited for the study. All participants were subjected to laboratory measurements of Lipid profile and Apo E genotyping tested by polymerase chain reaction&ndash;restriction fragment length polymorphism (PCR&ndash;RFLP) and abdominal ultrasound to assess abdominal aortic diameter and plaques. Results: the aortic plaques were significantly more frequent in the group of diabetics with cardiovascular complications compared to other groups (p= 0.026). And these plaques were significantly more frequent among E4 allele carriers in this group compared to E3 allele carriers in the same group (P=0.003). After pooling the overall subjects, there was significantly higher mean LDL among APO E4 carriers compared to E3 and E2 (P=0.02). Conclusion: APO E4 allele is associated with significantly higher plasma LDL levels in elderly while aortic plaque were significantly more frequent among E4 allele carriers among diabetics with cardiovascular complications.</p>