Association between Celiac Disease and Primary Biliary Cirrhosis– A Case Report

Dr. Hardeep SinghDeep; Dr. Barjinder Pal Singh; Dr. Roopa Chopra; Dr. Mridu Manjari

Volume : VI, Issue : II, February - 2016

Association between Celiac Disease and Primary Biliary Cirrhosis– A Case Report

Dr. Hardeep Singhdeep, Dr. Barjinder Pal Singh, Dr. Roopa Chopra, Dr. Mridu Manjari

Abstract :

Celiac Disease is an autoimmune disorder which mainly affects gastrointestinal tract causing malabsorption and chronic diarrhea. It is thought to result from the activation of both a cell–mediated (T–cell) and humoral (B–cell) immune response on exposure to the glutens of wheat, barley, rye, and rarely oats, in a genetically susceptible person. Primary Biliary Cirrhosis is a chronic cholestatic autoimmune disease with a progressive course of many decades leading to cirrhosis of liver. Both celiac disease and primary biliary cirrhosis share several features, including a higher prevalence in females, autoimmune comorbidities and specific autoantibodies. There is neither causative association between the two diseases nor the activity of one influences the course of the other, but presumably a shared susceptibility of biliary and small bowel epithelium to attack by autoimmune mechanisms can lead to association of both these diseases in the same patient. Here is a case report of a patient with coexistant celiac disease and primary biliary cirrhosis