Association between mucocutaneous manifestations and systemic involvement in childhood onset Systemic Lupus Erythematosus

Harikrishnan Bhaskaran; Suma Balan; Gayathri Subramoney; Renjitha Bhaskaran; Sekhar V. Easwar

Volume : X, Issue : VIII, August - 2020

Association between mucocutaneous manifestations and systemic involvement in childhood onset Systemic Lupus Erythematosus

Harikrishnan Bhaskaran, Suma Balan, Gayathri Subramoney, Renjitha Bhaskaran, Sekhar V. Easwar

Abstract :

Background: Certain mucocutaneous manifestations are associated with specific systemic involvement in systemic lupus erythematosus(SLE). Evidence about the same from India in childhood onset SLE(cSLE) is limited. Objective: To study the association of mucocutaneous manifestations with systemic involvement in cSLE. Method: This was a retrospective case control study. The patients consulted the pediatric rheumatology department between January 2012 and December 2018. Patients were diagnosed with cSLE by an experienced pediatric rheumatologist. The clinical manifestations at presentation were recorded and the association studied. Results: Out of 107 patients included in the study, 21 patients had no mucocutaneous manifestations at presentation. Hematological involvement was the most common systemic involvement. Mucosal ulcer was the most common mucocutaneous manifestation. Malar rash was associated with systemic involvement in males. Conclusion: cSLE without mucocutaneous manifestations can have severe disease at presentation. Malar rash was associated with systemic involvement in males.