Association between serum testosterone levels and metabolic syndrome in middle aged Indian men

John Jose; Kunal Gururani; Jegan Sivalingam

Volume : VI, Issue : VI, June - 2016

Association between serum testosterone levels and metabolic syndrome in middle aged Indian men

John Jose, Kunal Gururani, Jegan Sivalingam

Abstract :

 Background: Recent western studies suggest an association between serum testosterone and metabolic syndrome. Objective: To evaluate association between sex hormone levels and metabolic syndrome in adult Indian males. Study design and setting: A cross–sectional cohort study conducted in a single center tertiary care hospital. Subjects: Study included 31 adult males detected to have metabolic syndrome defined by standard criteria and 50 controls without metabolic syndrome. Main outcomes: Serum levels of total, free and bound testosterone, and sex hormone binding globulin. Results: The mean age of the study subjects and controls were 53 ± 6 and 53 ± 7 years, respectively. Men with metabolic syndrome had significantly lower levels of serum total testosterone, bound testosterone, free testosterone (8.7±3.1 versus 7.1±3.2,p=0.03) and sex binding globulin (38.2±12.3 versus 33.0±7.4,p=0.04). Conclusions: Low serum testosterone and sex binding globulin levels are associated with metabolic syndrome in middle aged Indian men