ASSOCIATION OF CA–125 LEVELS WITH SEVERITY OF LIVER CIRRHOSIS AND ASCITES

Bansal Apoorva; Gupta Rohit; Prakash Archana; Jayala N; Sarika Arora

Volume : IX, Issue : X, October - 2019

ASSOCIATION OF CA–125 LEVELS WITH SEVERITY OF LIVER CIRRHOSIS AND ASCITES

Bansal Apoorva, Gupta Rohit, Prakash Archana, Jayala N, Sarika Arora

Abstract :

Background: Elevated serum CA–125 levels have been used as pre–operative diagnostic and prognostic marker for ovarian malignancy, which may increase in certain non–gynaecological disorders also. Many cases of liver cirrhosis may be misdiagnosed as ovarian carcinoma due to combination of elevated CA125 and ascites. Aim– To determine association between elevated serum levels of cancer antigen (CA) 125 and severity and prognosis of patients presenting with liver diseases. Material and Methods – A total of 80 patients were enrolled in this study. There were 34 patients of acute liver disease, 12 patients of compensated cirrhosis and 34 patients of decompensated cirrhosis with ascites. Fasting LFT and CA –125 levels were measured in all patients. Ultrasound abdomen was carried out to assess severity of ascites. Statistical analysis was carried out on SPSS. P–value less than 0.05 was taken as significant Results– The mean CA–125 levels in patients of acute liver disease (n=34) was 8.39±4.83 U/mL, in patients of compensated cirrhosis (n=12) was 9.74±3.39 U/mL and 286.28±219.71 U/mL in patients of decompensated cirrhosis with ascites (n=34). Mean CA–125 levels were significantly higher in patients with ascites. A significant positive correlation was observed between serum CA–125 levels and severity of ascites ( p < 0.001). Conclusions – Serum CA–125 levels have high predictive value for determining severity and progression of liver disease.