Association of Gene Polymorphism of MIF, TLR4 and CD14 as A Potential Biomarker for Endometriosis

Ayapati Vikram Aiman; Ayapati Gautam Mehdi; Wajeeda Tabasum; Avinash Bardia; Roya Rozati

Volume : IX, Issue : II, February - 2019

Association of Gene Polymorphism of MIF, TLR4 and CD14 as A Potential Biomarker for Endometriosis

Ayapati Vikram Aiman, Ayapati Gautam Mehdi, Wajeeda Tabasum, Avinash Bardia, Roya Rozati

Abstract :

Endometriosis is the most frequent gynecologic disorder associated with pelvic pain and infertility. Numerous genetic polymorphisms in genes enclose the relationship among the polymorphisms and endometriosis. Present study was designed to know the effect of genetic polymorphism in immune related genes i.e.: CD14, MIF and TRL4 in endometriosis pathogenesis. From all women involved in the research, a 2mL of peripheral blood sample were collected to perform genotyping for CD14 –159C>T, MIF–173G>C and TRL4–299A>G. Variance in allelic and genotype frequencies was statistically evaluated between the control group and the group of patients. The analyzed group consisted of total 337 individuals of which 136 women were suffering from endometriosis and 201 were in the control group. C/T genotype of CD14, G/C genotype of MIF and A/G genotype of TLR4 gene was found to be predominant in patients when compare to control and which shows statistically significant. Homozygous variant for CD14 and MIF were also shown significant difference but small sample size was not taken into the consideration. This study shows genetic and functional polymorphisms in immune related genes might affect the disease pathogenesis. These Genes are also considered as biomarkers for diagnosis of endometriosis