ASSOCIATION OF HELICOBACTER PYLORI WITH DIFFERNTIATION OF GASTRIC ADENOCARCINOMAS – EXPERIENCE FROM A TERTIARY CARE CENTRE IN TAMILNADU,INDIA

Vajravelu Jayanthi; Amarapathy Sivasankar

Volume : VII, Issue : V, May - 2017

ASSOCIATION OF HELICOBACTER PYLORI WITH DIFFERNTIATION OF GASTRIC ADENOCARCINOMAS – EXPERIENCE FROM A TERTIARY CARE CENTRE IN TAMILNADU,INDIA

Vajravelu Jayanthi, Amarapathy Sivasankar

Abstract :

Background: Gastric carcinoma constitutes a leading cause of cancer related mortality. Aim: To study the association of Helicobacter pylori infection with the demographic parameters, site of occurrence and the grade of differentiation in gastric adenocarcinomas. Material and Methods: This is a retrospective study conducted in a tertiary care centre for a period of 3 years from 2012–2015. Random sampling of 50 consequetive gastrectomy specimens was done and tested for the presence of Helicobacter pylori infection. Results: Out of 50 cases of adenocarcinoma stomach, 39[78%] were males and 11[22%] were females. Among 39 male patients, 18 were H.pylori positive and out of 11 females, 7 were H.pylori positive. The prevalence of H.pylori was predominantly in the age group between 41–50 years. Regarding the site of occurrence, 41 cases were located in the antropyloric region and 9 at body fundus region. Out of 25 H.pylori infected cases, 20 were low grade and 5 were high grade adenocarcinomas. Conclusion: Helicobacter pylori is associated more often with low grade gastric adenocarcinoma. All asymptomatic high risk individuals should be tested for H.pylori infection and H.pylori positive patients should be treated prophylactically.