ASSOCIATION OF SERUM FERRITIN LEVEL WITH HEMATOMA EXPANSION IN PATIENTS OF SPONTANEOUS INTRACEREBRAL HEMORRHAGE

Introduction: ICH patients have rapid neurological deterioration due to ongoing bleeding and enlargement of the hematoma during the first few hours. Studies have implicated a strong relation between the level of serum ferritin and the edema surrounding the hematoma within 72 hr. We hereby aim to study the serum ferritin levels and correlate them with the hematoma volume on CT head.

Aims and objectives: Measurement of serum ferritin levels and hematoma expansion in patients of spontaneous ICH and studying the correlation of serum ferritin level with hematoma expansion in patients of spontaneous ICH.

Methods:This is an observational study patients with diagnosis of spontaneous ICH were included, their hematoma volume, absolute edema and relative edema was evaluated by CT head done on day 1 and 3 along with the ICH scores and serum ferritin levels.

Results:Mean age of patients was 56.94+10.85 years with majority of males. Mean day 1 and day 3 hematoma size was 28.85+44.46 and 22.88+19.82 cm³ respectively. Mean day 1 absolute edema size was 68.23+111.35 cm³. while mean day 3 absolute edema size of survivors was 77.45+82.06 cm³, Mean day 1 relative edema was 1.38+0.36. Mean day 3 relative edema of survivors was 2.38+1.16. At presentation, ICH score 1, 2 and 3 were seen in 39.2%, 37.3% and 23.5% patients.. Serum ferritin levels ranged from 10.92 to 1210.00 ng/ml. In multivariate analysis, only ICH score showed a significant association with outcome.

Conclusion:There was no significant association between S. ferritin levels and hematoma expansion in terms of absolute change in hematoma volume or absolute edema, but relative edema on day 3 showed a strong correlation with S. ferritin levels at presentation.