Volume : X, Issue : VIII, August - 2020

Association of serum ischemia modified albumin levels with lipid profile in early phases of acute coronary syndrome

Dr Sarika Arora, Rulie Buragohain, Prabhat Singh

Abstract :

Background: Acute coronary syndrome (ACS) is a medical emergency where diagnosis and management of patient before onset of myocardial necrosis is beneficial in reducing morbidity and mortality of the patients. Convential cardiac markers are able to detect ischemia only after onset of necrosis. The present study was carried out to evaluate the sensitivity of Ischemia modified albumin (IMA) in detecting ACS and correlation of IMA with lipid profile. Method: The study was carried out on 78 subjects (which included 38 cases of ACS and 40 controls). The diagnosis was made on the basis of clinical history, ECG, qualitative cTnI and estimation of CK–MB mass. Blood sample was collected for LFT, KFT, lipid Profile and Serum IMA. Result: A highly significant difference was observed in serum IMA levels and serum HDL levels between ACS cases and controls. IMA alone as well in association with the currently known biomarkers had a diagnostic sensitivity of above >90 % for detecting ischemia in ACS. Serum IMA levels showed a significant positive correlation with serum triglyceride levels and significant negative correlation with serum HDL. Conclusion: IMA is an early and highly sensitive marker, which can be utilized, for detection of myocardial ischemia before infarction sets in. Serum IMA levels have a positive correlation with dyslipidemia which needs further evaluation at molecular levels.

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

ASSOCIATION OF SERUM ISCHEMIA MODIFIED ALBUMIN LEVELS WITH LIPID PROFILE IN EARLY PHASES OF ACUTE CORONARY SYNDROME, Dr Sarika Arora, Rulie Buragohain, Prabhat Singh INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-8 | August-2020

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