Baseline resistance to ofloxacin and kanamycin among multi�drug resistant strains of M.tuberculosis isolated at an Intermediate reference laboratory in Delhi

Vasim Ahmad; Divya Shrivastsava; Mahmud Hanif; Zeeshan Sidiq; Kaushal Kumar Dwivedi; Himanshu Vashishtha; Srashty Sharma; Sanjeev Saini; Vinod Kumar Bediraddy; Kamal Kishore Chopra; Ashwani Khanna

Volume : VI, Issue : VIII, August - 2016

Baseline resistance to ofloxacin and kanamycin among multi�drug resistant strains of M.tuberculosis isolated at an Intermediate reference laboratory in Delhi

Vasim Ahmad, Divya Shrivastsava, Mahmud Hanif, Zeeshan Sidiq, Kaushal Kumar Dwivedi, Himanshu Vashishtha, Srashty Sharma, Sanjeev Saini, Vinod Kumar Bediraddy, Kamal Kishore Chopra, Ashwani Khanna

Abstract :

Prevalence of primary drug resistance serves as an epidemiological indicator to assess the success of the TB control programme. Thus early detection of Mycobacterium tuberculosis strains with primary resistance to antituberculosis drugs is important. We therefore conducted a study to estimate the prevalence of resistance at base line to two important second line anti–tuberculosis drugs i.e., Ofloxacin and Kanamycin among MDR–TB cases. 643 MDR strains were subject to drug susceptibility against Kanamycin and Ofloxacin using Bactec MGIT–960 system. DST results showed that 164 (29.63%) of these isolates were resistant to Ofloxacin, 3 (0.55%) resistant to kanamycin and 17 (3.17%) of these isolates were XDR. These results show that baseline resistance to second line antituberculosis drugs does occur and timely identification of such strains is important for formulating an effective treatment regimen.