Behavioural effects of alcoholic extract of different doses of Inula racemosa on mice–An experimental evaluation

Dr Salil Srivastava; Dr Meherunisa

Volume : VI, Issue : V, May - 2016

Behavioural effects of alcoholic extract of different doses of Inula racemosa on mice–An experimental evaluation

Dr Salil Srivastava, Dr Meherunisa

Abstract :

Objective: To evaluate the alcoholic extract of effect of Inula racemosa on behavioural aspects on mice. Methods: Behavioural effect of alcoholic extract of Inula racemosa was studied in mice with the help of Digiscan Animal Activity Monitoring system. Albino mice of either sex weight 25–30 gm had been used for this study. These mice were ed and raised in a laboratory. The mice were divided into four groups of six mice per group. Within each group, mice were administered per orally with one of the following incremented dose of drug dissolved in 1% gum acacia w/v solution in 0.9% sterile saline 2 ml/kg vehicle, 60. 120 and 240 mg/kg. Results: When treated with 60 mg/kg p.o. of alcoholic extract of Inula racemosa, a significant decrease was observed in the horizontal activity at 30 (p<0.001), 60 (p<0.001) and 90 (p<0.05) minutes and increased at 120 (p<0.05) minutes as compared to controls. When treated with 120 mg/kg, a significant decrease was observed in the horizontal activity, the total distance, movement time, sterotype counts, marginal time at 30 (p<0.001), 60 (p<0.001) and 90 (p<0.001) minutes. When treated with 240 mg/kg p.o. of alcoholic extract of Inula racemosa, a significant decrease was observed in the horizontal activity, total distance, movement time, sterotype counts, marginal time at 30 (p<0.001), 60 (p<0.001) and 90 (p<0.001) minutes and 120 (p<0.001) minutes. Conclusion: Inula racemosa has only mild sedative effect in therapeutic doses which was the common side effect of classical anti–histaminics