BIOCHEMICAL AND GENETIC STUDIES ON POLYCYSTIC OVARIAN SYNDROME AND ITS RISK ON CARDIOMETABOLIC SYNDROME

Revathy R; Muhammed Ashraf K; Sreerenj PP; Dinesh Roy D

Volume : VIII, Issue : VII, July - 2018

BIOCHEMICAL AND GENETIC STUDIES ON POLYCYSTIC OVARIAN SYNDROME AND ITS RISK ON CARDIOMETABOLIC SYNDROME

Revathy R, Muhammed Ashraf K, Sreerenj Pp, Dinesh Roy D

Abstract :

Polycystic Ovarian Syndrome is the major cause of anovulatory infertility and a common genetical endocrinopathy with a variety of clinical symptoms in women of reproductive age. It is characterized by anovulation, hyperandrogenism and polycystic ovarian morphology. A study was conducted to evaluate the biochemical and genetic studies on PCOS and its risk on cardiometabolic syndrome. There were 71 study subjects in the age group of 20 to 36 years and 33 age matched control subjects. Cytokinesis block micronuclei assay (CBMN) was carried out to measure the extent of somatic DNA damages. Serum lipid profile and hormonal analysis were also estimated in this era of all the subjects after obtained their informed consent. Obtained results were made to correlate with cardiometabolic risk. Decreased HDL and elevated levels of all other parameters were observed in the study subjects. A significantly elevated level of micronuclei (MN) in the study subjects along with the above parameters and body mass index (BMI) is increased risk of CVD in PCOS.