BIOCHEMICAL CHARACTERIZATION OF HYPOCHOLESTEROLEMIC ACTIVITY OF ETHANOLIC FLOWER EXTRACT OF BRASSICA OLERACEA L. VAR. ITALICA

V. RAMAMURTHY; K. DURGA DEVI

Volume : VII, Issue : III, March - 2017

BIOCHEMICAL CHARACTERIZATION OF HYPOCHOLESTEROLEMIC ACTIVITY OF ETHANOLIC FLOWER EXTRACT OF BRASSICA OLERACEA L. VAR. ITALICA

V. Ramamurthy, K. Durga Devi

Abstract :

The present study was designed to scientifically evaluate the hypocholesterolemic activity of ethanolic extract of Brassica oleraceae L. var. italica (Family: Brassicaceae), against hydrogenated oil (dalda) induced hypercholesterolemic rats. It is now widely accepted that atherosclerosis is a complex multicellular process involving oxidation of cholesterol and the intracellular accumulation of oxidized cholesterol. From ancient times, botanicals have played a major role in the lifestyle of people. The active phytochemicals derived from these herbs and plants have provided protection against atherosclarosis. The association of hypercholesterolemia with the development of atherosclerotic lesion has promoted widespread search for plant based compounds which effectively control the lipid profile in the blood and tissues with least or no toxic effect. Hypercholesterolemia was produced in rats with 100 mg/kg of dalda administered orally in 50 days. Effect of oral treatment of ethanolic extract of Brassica oleraceae L. var. italica at a dose (250 mg/kg body weight), was given simultaneously for 50 days. The present work was under taken to assess usefulness and toxic effects of the Broccoli extracts in dalda fed rats. Ethanolic extract of this plant showed significant hypocholesterolemic effect by lowering the serum levels of biochemical parameters like lipid, total cholesterol, phospholipid, triglycerides, LDL, VLDL cholesterol were estimated in the serum. Around eighty percent of the global population still relies on botanical drugs and herbal medicines have advanced to clinical use in modern times. Based on these findings, present work is written to identify the “Lipid–Lowering and Antioxidants Properties” of commonly used plants and herbs.