Volume : V, Issue : IX, September - 2015

Biochemical markers in pre and post menopausal women

Suma Susan Thomas, Z. G. Badade, Ayesha Zakira Shaikh

Abstract :

INTRODUCTION: –As part of the aging process, women above 45 years of age enter into the phase of menopause that leads to silent physical changes including osteoporosis and genito–urinary problems which are preventable to some extent. In the mean while, bones are constantly remodelled with old bone being replaced by new bone. However, the other main reason women experience rapid bone loss due to decline in estrogens during menopause. It is therefore, essential to identify these women at risk of developing osteoporosis. OBJECTIVE: – The study aimed at compå the levels of biochemical markers such as bone formation and bone resorption in pre and post menopause women. MATERIALS AND METHODS: – Study Design– Prospective and observational study. The study was carried out in the Department Of Biochemistry, MGM Medical College, and Navi–Mumbai. The study comprised of 50 pre–menopause women aged between 40–40 years were selected as control (group 1) with regular menses and no complications related to menstruation, whereas, 50 post–menopause women aged between 41–60 years were selected as (group2) with irregular menses and peri–menopause women (irregular menses that is before menopause) was also considered whereas, more than 1yr of menopause women were preferred more. RESULT: – There was a significant decrease in Serum Total Calcium and Phosphorous in postmenopausal women (p≤0.001). Similarly it was observed that bone formation markers i.e. Serum ALP, Serum Osteocalcin levels and bone resorption markers Acid Phosphatase and Urinary excretion of Hydroxyproline were significantly increased in postmenopausal Women compared to premenopausal women (p≤0.001) and there was strong correlation between ALP and urinary hydroxyproline (p≤0.001). CONCLUSION:–In our study after compå the biochemical parameter in pre and post menopause women we conclude that osteocalcin is increased which is a bone–turnover marker provide clues for bone–turnover and bone loss. This bone loss is seen in post menopause women due to lack of estrogen production and bone remodelling.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Suma Susan Thomas, Z.G.Badade, Ayesha zakira shaikh Biochemical Markers in Pre and Post Menopausal Women Indian Journal of Applied Research, Vol.5, Issue : 9 September 2015

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