Biochemical Studies on Effect of Sodium Nitrite and MonoSodium Glutamate (MSG) on Male Rats

Nashwa K. Khalaf; Sherif Y. Saleh; Abd El Rehim A. El Ghannam

Volume : VI, Issue : IX, September - 2016

Biochemical Studies on Effect of Sodium Nitrite and MonoSodium Glutamate (MSG) on Male Rats

Nashwa K. Khalaf, Sherif Y. Saleh, Abd El Rehim A. El Ghannam

Abstract :

Preservatives consider one of the most important food additives that used in most food industries like meat, fish, oil and others. The aim of the present study is to determine the effect of two `widely used preservatives, sodium nitrite and monosodium glutamate (MSG) on male rats by different doses. The experiment was carried out on 50 adult male rats weighing 150–200 gm. They have been divided into 5 groups,10 rats in each group (control group, second and third group were maintained on ration contains sodium nitrite at concentration 0.2% and 0.4% of the diet respectively, fourth and fifth group were maintained on ration contains MSG at concentration 0.04mg/ kg and 0.08 mg/kg of the diet respectively). Blood and tissue samples were collected after 6weeks from dietary manipulation. The biochemical results of sodium nitrite administrated rats showed significant increase in urea, creatinine, and MDA levels as well as glucose, ALT and AST levels. In addition, there were decrease in testosterone hormone, GSH, body weight and hemoglobin concentration. The biochemical results of MSG treated rats showed increase in body weight, urea, creatinine levels as well as MDA and glucose levels. Moreover, increase activity of ALT and AST were seen.