Volume : VII, Issue : VI, June - 2017

Carcinoma Cervix Presenting as Predominant lesion of Uterine Corpus: Posing Diagnostic & Management Dilemma

Gunjan Kumari, Anjali Tempe, Nidhi Verma, Nilanchali Singh

Abstract :

 Background: Squamous cell carcinoma of cervix extending to upper genital tract and presenting as predominant uterine tumour is rare. It should be distinguished from primary squamous cell carcinoma of endometrium. Case: A 60 yr old lady presented with postmenopausal bleeding. On examination cervix was flushed with vagina with no obvious growth, uterus was bulky in size with bilateral parametrium being free. Endometrial aspiration, endocervical curettage and colposcopy guided cervical biopsy revealed stratified squamous epithelium in all three biopsies and features of CIN I, II and focal areas of Carcinoma in Situ. MRI was suggestive of endometrial carcinoma. Extrafascial hysterectomy with bilateral salpingoophorectomy and lymph node sampling was perfomed. The specimen had ~4x5 cm growth in posterior myometrium with no endocevical growth. On histo–pathological examination endometrial growth had keratinising squamous cell carcinoma; cervix had focal areas of keratinising squamous cell carcinoma with extensive CIN III, without any continuity between cervix and endometrium. Case was thus diagnosed as keratinising squamous cell carcinoma of cervix extending to endometrium and left fallopian tube. Conclusion: To differentiate between primary squamous cell carcinoma of endometrium and squamous cell carcinoma of cervix spreading to upper genital tract a detailed histopathological examination is required. HPV DNA and p16 if available can be useful adjunct. More cases need to be reported for proper management guidelines to come up.  

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Gunjan Kumari, Anjali Tempe, Nidhi Verma, Nilanchali Singh, Carcinoma Cervix Presenting as Predominant lesion of Uterine Corpus: Posing Diagnostic & Management Dilemma, INDIAN JOURNAL OF APPLIED RESEARCH : Volume‾7 | Issue‾6 | June‾2017


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