Volume : VIII, Issue : VIII, August - 2018

CARCINOMA THYROID WITH AXIAL SKELETAL METASTASES: CASE SERIES OF 12 PATIENTS

Dinesh Shukla, Sanjay Chaube

Abstract :

Introduction:Role of surgery in axial skeletal metastases from carcinoma thyroid is unclear. In this study, we assess the role of surgery and adjuvant therapy such as radioiodine therapy in overall survival of these patients. Methods:  Twelve patients with biopsy proven spinal and cranial metastases from carcinoma thyroid were evaluated with respect to duration and mode of clinical presentation, physical examination, plain X–ray & MRI, operative and pathologic findings, adjunctive therapy such as131I treatment and outcome. Results:Five patients had metachronous and seven had synchronous metastases from carcinoma thyroid. There were 8 patients of spinal metastases, 2 patients of skull metastases and 2 patients with both skull and spinal metastases. Surgical treatment of metastatic foci was done which ranged from subtotal to total excision of the lesion. 131I therapy was administered following RAI (Radioactive iodine) assay for control of primary disease. There was no recurrence of skull site metastases in two patients in followup. One patient of skull metastases lost to follow up. All of the patients with verteal metastases had improvement in sensorimotor deficit and pain following surgery followed by 131Itherapy.One patient with follicular carcinoma thyroid who presented with spine and skull metastases expired following 5 years of surgery for skull metastases and cause of death could not be ascertained. Conclusions:Satisfactory result can be anticipated in cases of carcinoma thyroid with metastases, if aggressive surgical approach for primary tumor is taken along with adequate management of metastases. Most of the metastasic foci are highly vascular and excision followed by radioiodine therapy result reasonably good outcome.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

DINESH SHUKLA, SANJAY CHAUBE, CARCINOMA THYROID WITH AXIAL SKELETAL METASTASES: CASE SERIES OF 12 PATIENTS, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-8 | August-2018

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