CBNAAT IN DIAGNOSIS OF PULMONARY AND EXTRA PULMONARY TUBERCULOSIS IN A TERTIARY CARE HOSPITAL

DR. KAKUMANU SUVARNA; DR. BOKAM BHANU REKHA; DR. V. M. KIRAN OGIRALA

Volume : X, Issue : II, February - 2020

CBNAAT IN DIAGNOSIS OF PULMONARY AND EXTRA PULMONARY TUBERCULOSIS IN A TERTIARY CARE HOSPITAL

Dr. Kakumanu Suvarna, Dr. Bokam Bhanu Rekha, Dr. V. M. Kiran Ogirala

Abstract :

INTRODUCTION: Tuberculosis is the ninth leading cause of death worldwide. Tuberculosis incidence in India is 2.74 million including 0.13 million drug resistant cases. According to WHO 0.41 million deaths in India are due to tuberculosis in 2017. Sputum smear microscopy is facing variable sensitivity issue particularly in sputum smear–negative, extrapulmonary disease and drug–resistant Tuberculosis. Conventional solid culture techniques take long turnaround time of 2–6 weeks and is costly. To overcome this problem, WHO current policies and guidance recommend to use Xpert MTB/RIF as an initial diagnostic test. AIM: To study the utility of CBNAAT in diagnosis of Pulmonary and Extrapulmonary tuberculosis . RESULTS: Among 313 samples, 149 were pulmonary and 164 were extra pulmonary. Among 149 pulmonary samples, 70 (46.97%) were sputum smear positive whereas MTB was detected in 109 (73%) samples through CBNAAT. Out of 109 samples, 106 samples were found to be rifampicin sensitive and 3 (4.2%) were rifampicin resistant. 40 (26.8%) samples that were negative for CBNAAT subjected to onchoscopy, MTB was detected in 10 cases (25%) in BAL CBNAAT which were rifampicin sensitive . Extra pulmonary samples (164) yielded 16 (9.8%) positive result for MTB and 0% rifampicin resistance. CONCLUSION: CBNAAT is a simple, rapid and a better diagnostic test for detection of pulmonary and extra pulmonary tuberculosis. Enhanced diagnostic yield for smear negative pulmonary and extra pulmonary tuberculosis is well documented.