Celiac Disease in Children with Short Stature

DR.SATISH KUMAR; DR.SIDDHARTHA NANDI

Volume : VI, Issue : VI, June - 2016

Celiac Disease in Children with Short Stature

Dr. Satish Kumar, Dr. Siddhartha Nandi

Abstract :

 Objective. The aim of the present study was to determine the prevalence of celiac disease in children with short stature. Methods. In all children with short stature (height more than 2 SD below the mean for age and sex) and normal physical examination, attending deptt.of paediatrics jlnmch BHAGALPUR, from 2014 till 2015, work–ups were made to find a cause for their short stature and of course their serum was assayed for IgG anti–tissue transglutaminase (TTG) antibody by ELISA test, as a marker for CD. Results. There were 26 girls and 46 boys with mean age of 9.8 years, Routine work–up showed microcytic hypochromic anemia in four children (5.6%) and giardiasis in five (6.9%). GH stimulation test revealed GH deficiency in five children (6.9%) Elevated IgG anti–TTG antibody level was detected in two children (2.8%). Duodenal biopsies of these children were in favour of celiac disease. Conclusion. Although, the prevalence of CD in this study was not significantly different (P value=0.14) from the prevalence rate in healthy blood donors in INDIA, the findings emphasize the fact that CD must be considered in a child with short stature, especially if the height is more than 3 SD below the mean for sex and age, even in the absence of gastrointestinal symptoms,. In conclusion, the measurement of anti–TTG antibody should be included in the diagnostic avaluation of children with short stature