Challenges in interpretation of eosinophilia associated with leukemia: case report of two cases

DAMBHARE POONAM T; SINGH VANDITA Y

Volume : X, Issue : VIII, August - 2020

Challenges in interpretation of eosinophilia associated with leukemia: case report of two cases

Dambhare Poonam T, Singh Vandita Y

Abstract :

Eosinophilia is a condition that develops when bone marrow makes too many eosinophils. It can be reactive or caused by a new genetic mutation. Here we are discussing two cases, one is idiopathic hypereosinophilic syndrome (HES) and other case is acute myeloid leukemia associated with eosinophilia (AMLEo). In AMLEo, causative role and impact of eosinophilia was uncertain. Cytogenetic and molecular genetic techniques do help for the evidence of clonality of the eosinophils and for identifying patient with respect to imatinib sensitivity and resistance. Eosinophils in patients with myeloid or stem cell derived neoplasm usually belong to the malignant clone. But in a resource limited settings, it is challenging for a pathologist for proper diagnosis of such cases wheather to overlooked or ignore such eosinophilia present in a leukemia and to differentiate HES from chronic eosinophilic leukemia.