Volume : IV, Issue : I, January - 2014

Changes in Learning and Memory in Pentylenetetrazole Induced Amnesia of Rats Treated with Lacosamide

M. Shishmanova, L. Peychev, K. Georgieva

Abstract :

Cognitive impairments are frequently observed in epileptic patients. It is known, that not only epilepsy but also antiepileptic drugs can induce cognitive and behavioural abnormalities. Lacosamide (LCM) is a new antiepileptic drug and its effect on cognitive functions is not fully elucidated. The aim of the study was to assess the effect of Lacosamide on the cognitive functions in a drug-induced model of amnesia with pentylenetetrazole (PTZ) in rats. The controls increased avoidances in learning and memory sessions. Lacosamide administration to kindled animals led to a slight increase of the number of active avoidances compared with PTZ controls and restored motor activity suppressed by PTZ. The therapeutic dose of LCM shows a tendency towards a neuroprotective effect on cognitive functions in the PTZ kindling model in rats.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

M. Shishmanova, L. Peychev, K. Georgieva Changes in Learning and Memory in Pentylenetetrazole Induced Amnesia of Rats Treated with Lacosamide Indian Journal of Applied Research, Vol.IV, Issue. I

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