Volume : V, Issue : IV, April - 2015
Charectarization and Validation of Cefixime Trihydrate Tablets with Ftir and Rp–Hplc Techeniques
Prof. I. P. Tripathi, Dr. Priyanka Gupta, Dr. Mahesh Gupta, Aarti Kamal
Abstract :
Drug compatibility with excipients was checked by HPLC and FTIR studies. An accurate, Precise, Simple and Economical High Performance Liquid Chromatographic method for the estimation of Cefixime
was developed and validated. The method so developed is Reverse Phase High Performance Liquid Chromatographic
method using shimadzu (Japan) C–18 (5µ, 250×4.6mm) with a tetrabutyal ammonium hydroxide buffer adjusted with
Ortho phosphoric acid (pH 6.5). Flow rate of 1ml/min and UV detection at 254nm linearity was observed over concentration range of 100–300 μg/ml. the accuracy of the proposed method was determined by recovery studies and found
to be 95–101%. The proposed method was validated and results conformed to ICH parameters.
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DOI : 10.36106/ijar
Cite This Article:
Prof. I. P. Tripathi, Dr. Priyanka Gupta, Dr. Mahesh Gupta, Aarti Kamal Charectarization and Validation of Cefixime Trihydrate Tablets with Ftir and Rp–Hplc Techeniques Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015
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Prof. I. P. Tripathi, Dr. Priyanka Gupta, Dr. Mahesh Gupta, Aarti Kamal Charectarization and Validation of Cefixime Trihydrate Tablets with Ftir and Rp–Hplc Techeniques Indian Journal of Applied Research, Vol.5, Issue : 4 April 2015
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