CHARECTARIZATION AND VALIDATION OF CHLOROQUINE TABLETS WITH FTIR AND AAS TECHENIQUES

Prof. I. P. Tripathi; Dr. Priyanka Gupta; Dr. Mahesh Gupta; Aarti Kamal

Volume : V, Issue : V, May - 2015

CHARECTARIZATION AND VALIDATION OF CHLOROQUINE TABLETS WITH FTIR AND AAS TECHENIQUES

Prof. I. P. Tripathi, Dr. Priyanka Gupta, Dr. Mahesh Gupta, Aarti Kamal

Abstract :

 Drug compatibility with excipients was checked by HPLC and FTIR studies. An accurate, Precise, Simple and Economical High Performance Liquid Chromatographic method for the estimation of Cefixime  was developed and validated. The method so developed is Reverse Phase High Performance Liquid Chromatographic  method using shimadzu (Japan) C–18 (5µ, 250×4.6mm) with a tetrabutyal ammonium hydroxide buffer adjusted with  Ortho phosphoric acid (pH 6.5). Flow rate of 1ml/min and UV detection at 254nm linearity was observed over concentration range of 100–300 μg/ml. the accuracy of the proposed method was determined by recovery studies and found  to be 95–101%. The proposed method was validated and results conformed to ICH parameters.