Volume : VIII, Issue : VI, June - 2018

Cirrhosis in children – Experience from a tertiary care centre

Sujay Chaudhuri

Abstract :

Objectives– To evaluate  incidence, etiology and clinical profile of cirrhosis in children in a northern city of India. This study was conducted.

Methods:–

The children (less than 12 years) who attended pediatric gastroenterology OPD in PGIMER Chandigarh from July 2000– June 2003 with symptom of chronic liver disease (abdominal swelling, pedal edema, jaundice, high colored urine , clay colored stool, GI bleed , encephalopaphy, family history of liver disease in siblings etc.) were enrolled for the study. Detailed history , clinical examination , investigation (USG whole abdomen, LFT, PTI,HIDA scan , per operative cholangiogram, TORCH infection profile, enzyme study for metabolic disease like galactosemia, alfa one antitrypsin deficiency , glycogen storage disease , serum cerulospasmin , urinary copper, slit lamp examination for KF ring, auto immune marker like ANA, SMA,LKM, viral marker , UGI endoscopy, liver biopsy , liver copper estimation , ultrasound Doppler examination of hepatic veins etc.) were done.

Results:–

Out of 50 total cases of cirrhosis , 10 (20%) were biliary atresia who came late for surgery , 5 (10%) had galactosemia, 1(2%) had alfa one antitrypsin deficiency , 1 (2%) had glycogen storage disease, 10(20%)had Wilson’s disease , 10 (20%)had auto immune hepatitis , 7(14%) had Indian childhood cirrhosis, 1(2%) had neonatal hepatitis , 5 (10%) had Budd Chiari syndrome. Out of 50 cases , 25 (50%) had esophageal varices  in UGI endoscopy. Out of 10 Wilson’s disease  3(30%) came with fulminant condition where postmortem liver biopsy was done.

Conclusion:–

Cirrhosis in children is an important problem. Etiological diagnosis is important to prevent its progress.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Sujay Chaudhuri, Cirrhosis in children – Experience from a tertiary care centre, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-6 | June-2018

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