CISATRACURIUM IN DIFFERENT DOSES VERSUS ATRACURIUM DURING GENERAL ANESTHESIA FOR ABDOMINAL SURGERY A PROSPECTIVE, RANDOMIZED CLINICAL TRIAL

Dr Mridu Paban Nath; Dr Avishrant Gogoi

Volume : X, Issue : II, February - 2020

CISATRACURIUM IN DIFFERENT DOSES VERSUS ATRACURIUM DURING GENERAL ANESTHESIA FOR ABDOMINAL SURGERY A PROSPECTIVE, RANDOMIZED CLINICAL TRIAL

Dr Mridu Paban Nath, Dr Avishrant Gogoi

Abstract :

Background and objective: This study was aimed at compå the efficacy of atracurium and cisatracurium (in different doses) regarding onset time, intubating conditions and hemodynamic effects in patients undergoing elective abdominal surgery. Methods: – This Randomized, double–blind, single Hospital, Prospective study, was carried out after institutional ethical committee clearance. Hundred and twenty patients aged 18 to 60 years belonging to ASA classes I and II undergoing, elective abdominal surgery were randomly allocated into 3 groups– Group A (n=40): Inj cisatracurium 0.1 mg/kg(2 ED 95),Group B(n=40): Inj Cisatracurium 0.15mg/kg(3 ED 95) and Group C(n=40): Inj Atracurium 0.5mg/kg(2 ED 95). Onset time, Intubating conditions and hemodynamic parameters were compared between the 3 groups. Results: The demographic parameters and baseline hemodynamic variables were comparable and statistically not significant. The intubating condition and onset time of Group A when compared to Group B and Group C were statistically significant, whereas in–between Group B and C were nonsignificant. Hemodynamic parameters at 0,1,3,5 mins after intubation were comparable and nonsignificant. Conclusion: From our clinical comparative study, we have observed that intubating conditions with 3 ED 95 cisatracurium and 2 ED 95 atracurium are comparable and significantly better than 2 ED 95 cisatracurium. The onset time in 2 ED 95 Cisatracurium was significantly longer when compared to 3 ED 95 cisatracurium and 2 ED95 Atracurium. No significant hemodynamic changes were noted in any of the three groups