Volume : VII, Issue : X, October - 2017

CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION OF PATIENTS WITH DIABETIC NEUROPATHY

Kannan Vellaichamy, Thamil Pavai N, Lakshminasimhan R, Bhanu K, Natarajan V

Abstract :

 Peripheral neuropathy caused by Diabetes (DM) was recognised only in 1864 by Marchel de Calvi.(1) Till then it was assumed that diabetes was caused by disease of the nervous system. However, once the relationship was rightly recognised, much documentary evidence soon emerged regarding the various clinical manifestations occurring in diabetic peripheral neuropathy. Thus, the loss of tendon reflexes in the legs was described by Bouchard (1887),(2) similarities to tabes stressed by Althaus (1885)(3), spontaneous pain and hyperesthesia by Pavy (1885)(1904)(6) and motor manifestations by Bruns (1890)(6) and Charcot (1890) and cranial nerve involvement by Ogle (1896).(8) While Leyden (1893)(9) and Pryce (1893)(10) set out a classification of the different manifestations of the disease, is was Rundles11 who in 1945 first drew attention to the autonomic nerve involvement in diabetes. Later, scientists turned their interest to the etiopathogenetic mechanisms resulting in peripheral neuropathy. This in turn gave impetus to the experimental production of diabetic neuropathy (DN) in order to understand the evolution of the disease. Though a large volume of work has been carried out in this regard and many problems solved, many questions still remain unanswered. There is a need, therefore, for more comprehensive  studies of the prevalence, severity,  natural history, and cause of specific  types of diabetic neuropathy.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Kannan Vellaichamy, Thamil Pavai N, Lakshminasimhan R, Bhanu K, Natarajan V, CLINICAL AND ELECTROPHYSIOLOGICAL EVALUATION OF PATIENTS WITH DIABETIC NEUROPATHY, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-7 | Issue-10 | October-2017

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