Clinical Profile of Hepatic Dysfunction in Dengue

Dr.Rajesh Karekar; Dr.Bhagwan Gore

Volume : VI, Issue : IX, September - 2016

Clinical Profile of Hepatic Dysfunction in Dengue

Dr. Rajesh Karekar, Dr. Bhagwan Gore

Abstract :

•Background: An analysis of 60 patients suffering from dengue showed liver dysfunction was present in all patients. Hepatosplenomegaly and ascitis were also present in significant number of patients. SGOT levels were higher than SGPT levels. 7 patients presented with macrophage activation syndrome (MAS). Ultrasonography revealed gall bladder wall edema, altered liver texture, ascitis, perinehpric fluid collection. Clinicians should take a note of these clinical finding while dealing with dengue fever patients. •Results: Out of 60 patients 54%had hepatomegaly,78%SGOT increased, 45% had increased SGPT, 12% had X–Ray evidence of pleural effusion, 7 patients had macrophage activation syndrome, most common symptom being fever. •Conclusion: In a tropical country like India there are various viral, bacterial infections, including dengue,malaria, leptospirosis, most of which have got multiorgan dysfunction. A high index of suspicion is required for diagnosing Macrophage Activation Syndrome in which there is cytokine storm which needs immunosupressive therapy in the form of corticosteroids or combination of corticosteroids and immunosuppressive agents both.