Volume : V, Issue : IX, September - 2015

Clinical profile of malaria in Adults

Dr. Pradeep T. V, Dr. Steffy Kuriakose

Abstract :

Background : Malaria remains the most important human parasitic infection globally and continues to pose a major public health threat in India , particularly due to plasmodium falciparum which is prone to complications. Hence the study was undertaken to analyse various types of clinical presentation of Malaria in Adults , its complications and response to treatment guidelines followed by The National Vector Borne Disease Control Programme(NVBDCP). Materials and Methods: A cross sectional study of 50 patients with positive lab results , aged more than 15 years were included in study. Patients with history of allergy to antimalarials and who cannot be followed for initial 5 days were excluded. Average number of parasites was calculated for initial 5 days .Based on treatment ,patients were divided into early(ETF) and late treatment failure(LTF) group and adequate clinical response group(ACR). NVBDCP Treatment guidelines are based on WHO advised drug regimen for South East Asia region .Artesunate combination therapy (ACT) was used in patients with treatment failure groups. Results : 25 patients(pts) had P.vivax and 25 had P.falciparum. No siginificant difference in age distribution was observed. Most common symptom was fever 98% and commonest sign was splenomegaly 80% with serum bilirubin, elevated in 48% patients .6 pts had multiple organ dysfunction.There was significant reduction in daily parasite count and body temperature in initial 5 days after treatment .32 pts responded to chloroquine and primaquine therapy(CQ+PQ) (64%) and 18 pts to second line drugs.Among P.vivax , all pts showed ACR but 14 out of 25 in P.falciparum group showed ACR and 11 had ETF. out of 14 pts in ACR in Falciparum group 7 reponded to CQ+PQ therapy & 7 responded to second line drugs . Conclusions : Use of ACT in complicated malaria as advised by NVBDCP especially in high falciparum failure areas prevents deaths. Hence use of combination drugs in treating complicated &resistant cases helps in reducing complications.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr PRADEEP T.V., Dr.STEFFY KURIAKOSE Clinical Profile of Malaria in Adults Indian Journal of Applied Research, Vol.5, Issue : 9 September 2015

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