Volume : V, Issue : X, October - 2015

Clinico pathological profile and etiological diagnosis in patients of Pancytopenia.

Rajesh Chetiwal, Sharath Kumar Jv, Manoj Lakhotia

Abstract :

 Background: There has been a wide variation of etiological diagnosis of Pancytopenia and its clinical presentation. This can be attributed to difference in methodology and stringency of diagnostic criteria, geographic area, period of observation, nutritional status and varying exposure to myelotoxic drugs. There are limited number of studies in Indian subcontinent and few studies are available from the other parts of the worlds on the frequency of various causes. Objective : To Analyze the clinico pathological profile in pancytopenia. To identify various causes of pancytopenia. Study design : Prospective observational study, on 210 Subjects of pancytopenia older than 13 years, meeting inclusion criteria during the period of 18 months since January 2010 , were included. Methodology : The study was conducted at tertiary care teaching institute. detailed clinical and laboratory workup was done including complete blood count, peripheral smear examination, serum Lactate Dehydrogenase, bone marrow aspiration, biopsy and staining with special stains. Results : In our study 210 cases of pancytopenia 116 (55.3%) were males and 94 ( 44.7%) females. The majority of the patients were in younger age group 13 – 30 years (64.7%). Megaloblastic anemia was the most common cause of pancytopenia in 83 (39.52%) , followed by aplastic anemia in 57 (27%), malaria in 17 (8.09%) and hypersplenism in 16 ( 7.61%) of patients. Acute leukemia, myelodysplastic syndrome, SLE, HBV , multiple myeloma, and sepsis were uncommon etiology. Conclusion : Megaloblastic anemia and aplastic anemia were amongst the common etiological diagnosis of pancytopenia, comparising 2/3 of all cases. Severe Anemia was more common in megaloblastic anemia. Where is thrombocytopenia was more common in patients of aplstic anemia, resulting bleeding manifestations.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Rajesh Chetiwal, Sharath Kumar JV, Manoj Lakhotia Clinico Pathological Profile and Etiological Diagnosis in Patients of Pancytopenia. Indian Journal of Applied Research, Vol.5, Issue : 10 October 2015

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