Volume : IV, Issue : V, May - 2014

Clomiphene Citrateplus N–Acetyl Cysteine, Chromium Picolinate Plus Clomiphene Citrate Versus Clomiphene Citrate Alone In Management Of Pcos

El 45 Gharib Mn, Osman Am

Abstract :

 Aim of the work:The purpose of this study was to compare the efficacy and safety of clomiphene citrate 

(CC) alone versus CC plus N–acetyl cysteine (NAC) and CC plus chromium picolinate (CrP) in management of 
PCOS.
? Patients and Methods: This study, accomplished on 120 women with PCOS and fulfilling Rotterdam criteria 2003. Patients were divided into three equal groups; the FirstGroup (n=40) given outNAC plus CC. The second group (n=40) administered Crp plus CC. The last group (n=40) dispensed CC alone.
? Results:The number of follicles (≥18 mm), mean endometrial thickness on the day of hCG administration and number of 
pregnancies were higher among PCOS cases given NAC+CC group than CrP+CC and CC alone cases. No adverse sideeffects and one case of ovarian hyperstimulation syndrome observed in the group receivingCC+ NAC.
? Conclusion:NAC is a safe and well–tolerated adjuvant to CC. It improves follicular maturation and pregnancy rate in 
PCOS patients.In addition, chromium picolinate does not improve follicular maturation or pregnancy rate when added to CC 
in women with PCOS.

Keywords :

Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

EL-Gharib MN, Osman AM Clomiphene Citrateplus N–Acetyl Cysteine, Chromium Picolinate Plus Clomiphene Citrate Versus Clomiphene Citrate Alone In Management Of Pcos Indian Journal of Applied Research, Vol.4, Issue : 5 May 2014


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