Volume : X, Issue : VIII, August - 2020

Cognitive Effect of Mahapaishachik Ghrita in Diazepam Induced Amnesia in Adult Mice.

Dipali S Kashid, Sarita M Kapgate

Abstract :

BACKGROUND: Learning is an acquisition of information and skills whereas retention of the acquired information is called memory. Diazepam (DZP), widely prescribed agent for anxiety, depression and insomnia of old age is associated adverse effect of amnesia which further worsens the natural neurodegenerative amnesia of old age. Hence present study was undertaken to explore effect of Mahapaishachik Ghrita (MG), a fat based Ayurvedic formulation in learning, memory and Diazepam induced amnesia in adult mice. AIM: To assess nootropic and anti– amnesic effect of Mahapaishachik Ghrita (MG) in adult Swiss albino mice. METHOD: The experiment was conducted on adult mice of age 52–53 wks in five groups as Normal control, Disease control and standard control with known memory enhancer drug Rivastigmine (RV) (dose=2.4mg/kg/p.o.) and two groups of MG in two doses (MG1=5.2 gm /kg/p.o., MG2= 10.4 gm / kg/p.o.). Effect of MG on learning was assessed on day 15 & on memory was assessed on day 16, whereas diazepam induced amnesia (dose=1mg /kg/i.p.) was noted on 26 and 27 day. The transverse latency of the animals in extroceptive behavioral animal models – EPM & MWM were employed to assess learning and memory. RESULTS: The higher dose of MG showed less TL, compared to standard (Rivastigmin)and diseases (Diazepam) control group. MG also demonstrated significant ameliorative effect in Diazepam induction amnesia. The obtained results may be contributed to the nootropic ingredients of the MG. CONCLUSION: MG demonstrates nootropic effect in adult mice and also prevents Diazepam induction amnesia

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Article: Download PDF    DOI : 10.36106/ijar  

Cite This Article:

COGNITIVE EFFECT OF MAHAPAISHACHIK GHRITA IN DIAZEPAM INDUCED AMNESIA IN ADULT MICE., Dipali S Kashid, Sarita M Kapgate INDIAN JOURNAL OF APPLIED RESEARCH : Volume-10 | Issue-8 | August-2020


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