IJAR - Indian Journal of Applied Research

Aditendraditya Singh Bhati; Aarjun Tyagi; Sudheer K Tyagi

Volume : VII, Issue : X, October - 2017

Combined use of Hyperbaric Oxygen and Stem Cell Therapy in management of severe traumatic brain injury – A case report

Aditendraditya Singh Bhati, Aarjun Tyagi, Sudheer K Tyagi

Abstract :

Standard treatment of acute traumatic ain injury (TBI) consists of either conservative or removing the clot (surgery), restoring perfusion, supporting metabolic requirement and limiting inflammatory and oxidative damage. Many centres worldwide are researching newer modalities for better outcomes. As a result, the survival rate of patients with TBI has increased significantly. Hyperbaric oxygen (HBO) therapy has been shown to protect neurons from the damaging effect of hypotension and ischemia, improve neuronal aerobic metabolism, promote mobilisation of stem cells. In the regenerative medicine, hematopoietic stem cell transplantation is evolving as a promising treatment modality in various neurological disorders like multiple sclerosis, Parkinson’s disease and stroke with varying clinical outcome. This case report of a 21 year old boy, suggests that hyperbaric oxygen in combination with stem cell therapy along with neuro–rehabilitation has a potential to reverse the damage after TBI leading to an improved quality of life in head injury patients.