Volume : VIII, Issue : IV, April - 2018

Comparative analysis of anticoagulant efficacy between heparin and bivalirudin during percutaneous transluminal coronary angioplasty

Dr. Kavya Annapareddy, Dr. M. Kaleemullah Khan, Dr. Syed Mohammed Ali

Abstract :

The aim of the present study is to investigate efficacy of the anti–coagulants bivalirudin versus heparin across the spectrum of acute coronary syndrome (ACS). It is a prospective, open labelled, observational comparative study carried out at Princess Esra Hospital and Owaisi Hospital and Research Centre, Hyderabad.Anti–coagulant efficacy of heparin and bivalirudin was compared in ACS cases undergoing percutaneous coronary intervention (PCI) by assessing major adverse cardiovascular events (MACE). The number of cases receiving heparin was 120 and those receiving bivalirudin was 103.Assessment of net adverse clinical events (NACE) and stent thrombosis was done at 30 days and one year after the procedure. The proportion of cases for baseline characteristics such as gender, smokers, cases with hypertension, with angina, STEMI, and NSTEMI were comparable in both heparin and bivalirudin groups. However, the number of diabetics was 77 out of 103 (74%) in bivaluridin group and 60% (72 out of 120) in the heparin group. It is concluded that all the patients with ST–elevation myocardial infarction (MI) should be treated withanti–coagulant therapy as soon as possible after the diagnosis. The choice of anti–coagulant agent should depend upon the treatment strategy and condition of each patient. Bivaluridin has been found to be associated with less incidences of bleeding (Major bleeding one case (0.8%) in heparin group while none in the bivalirudin group). However, higher rates of stent thrombosis were recorded in bivalirudin group (5 cases 4.9%) compared to only 2 cases (1.7%) in the group on heparin (p<0.05)). Further studies are required to prove superiority of bivalirudin over heparin interms of clinical outcomes.

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Article: Download PDF   DOI : 10.36106/ijar  

Cite This Article:

Dr. Kavya Annapareddy, Dr. M. Kaleemullah Khan, Dr.Syed Mohammed Ali, Comparative analysis of anticoagulant efficacy between heparin and bivalirudin during percutaneous transluminal coronary angioplasty, INDIAN JOURNAL OF APPLIED RESEARCH : Volume-8 | Issue-4 | April-2018

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