Comparative Clinical Study Between Premixed and Sequential Administration of Intrathecal Clonidine With Hyperbaric Bupivacaine in Lower Limb Orthopedic Surgeries

Jyoti Pushkar Deshpande; Poonam S. Ghodki; Shalini Sardesai

Volume : V, Issue : III, March - 2015

Comparative Clinical Study Between Premixed and Sequential Administration of Intrathecal Clonidine With Hyperbaric Bupivacaine in Lower Limb Orthopedic Surgeries

Jyoti Pushkar Deshpande, Poonam S. Ghodki, Shalini Sardesai

Abstract :

Context: Clonidine alpha–2 agonist is used as adjuvant to intrathecal local anesthetic to improve intraoperative analgesia and to prolong sensory and motor block. We compared hyperbaric bupivacaine(HB) with intrathecal clonidine injected as premixed or in sequential manner. Aims: 1: To study sensory and motor block characteristics. 2: Postoperative analgesia. Settings and Design: Prospective randomized double blind study. Methods and Materials: Sixty patients of either sex, age 18–65 years, ASA grade I or II undergoing lower limb orthopedic surgeries were randomly assigned to one of the following group of 30 each, using a slip in box technique: Group M: Received mixture of 0.5% HB 15mg & Clonidine45ug. Group S: Received 0.5% HB 15mg followed by Clonidine45ug in a separate syringe. Statistical analysis: Two independent sample t– test used and p value ≤ 0.05 was statistically significant. Results: .Time to reach highest sensory level and highest omage scale were less in group S when drugs administered sequentially. Prolonged duration of analgesia was seen in group S compared to group M. Conclusions: Sequential technique hastens the onset of complete sensory and motor block, enhances the duration of sensory and motor block also the postoperative analgesia without much hemodynamic adverse effect.