Comparative Evaluation Of Olanzapine Versus  Haloperidol on Depressive Symptoms Using  Montgomery Asberg Depression Rating Scale  (Madrs) in Stable Schizophrenic Patients

Bhardwaj Reena; Bhardwaj Praveen; Dutta Shaktibala; Kaul Vijay; Dhasmana D.C

Volume : IV, Issue : III, March - 2014

Comparative Evaluation Of Olanzapine Versus Haloperidol on Depressive Symptoms Using Montgomery Asberg Depression Rating Scale (Madrs) in Stable Schizophrenic Patients

Bhardwaj Reena, Bhardwaj Praveen, Dutta Shaktibala, Kaul Vijay, Dhasmana D. C

Abstract :

Objective : To evaluate the efficacy among newer atypical antipsychotic agent, olanzapine versus conventional antipsychotic, haloperidol on depressive symptomatology. Material and methods : An open label randomized prospective study was conducted in stable schizophrenics for 12 weeks. A total number of 20 patients diagnosed according to DSM–IV criteria were divided into two groups. Group I (n=10) received olanzapine (5–20mg/day) and Group II received haloperidol (5–20mg/day) orally in divided doses. Evaluation of changes on depressive signs and symptoms was done by MADRS scores. Results: Intragroup comparison showed significant reduction (p