Comparative nephroprotective effect of Cinnamomum cassia and Zingiber officinal on diabetic Rat

Asif Iqubal; Arun Kumar Singh; Sunil Kumar Singh; Md Ali; Arun Kumar; Ranjit Kumar

Volume : IX, Issue : XII, December - 2019

Comparative nephroprotective effect of Cinnamomum cassia and Zingiber officinal on diabetic Rat

Asif Iqubal, Arun Kumar Singh, Sunil Kumar Singh, Md Ali, Arun Kumar, Ranjit Kumar

Abstract :

Diabetes is exponentially growing disease in developed and developing country in last few decades. Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycaemia. Alloxan were introduced intra–peritoneally @ 125 mg/kg/b.w to prepare diabetic model. Diabetic control group rat were treated with distilled water while diabetic rat were treated with Cinnamomum cassia @ 100 mg/kg/b.w and Zingiber officinale @ 200 mg/kg/b.w separately for 8 weeks. Glucose level was increased many folds in diabetic rat. Urea, uric acid, creatinine and LPO were increased in diabetic group of rat. Cinnamon and ginger restores urea, uric acid, creatinine and LPO effectively after 8 weeks of administration. It is concluded from entire study that cinnamon and ginger both acts very effectively against diabetes on biochemical parameters of rat. Both restore glucose level to normal level. Cinnamon effectively restores KFT and LPO very well in comparison to ginger administered group. It was evident from study that cinnamon causes more effective restoration in biochemical parameters of rat.