Comparative study of Clomiphene Citrate VS Clomiphene Citrate + N�acetyl Cysteine in Polycystic ovarian disease patient.

Dr. Geeta Rani; Dr Bindu Sinha

Volume : VII, Issue : III, March - 2017

Comparative study of Clomiphene Citrate VS Clomiphene Citrate + N�acetyl Cysteine in Polycystic ovarian disease patient.

Dr. Geeta Rani, Dr Bindu Sinha

Abstract :

OBJECTIVE – To evaluate the effect of N–acetyl cysteine, a mucolytic drug with insulin sensitizing properties as an adjuvant therapy in patients of PCOD. MATERIALS AND METHODS– One hundred women diagnosed with PCOD, aged between 18–39 years undergoing therapy for infertility were included, patients were randomly assigned to receive either N–acetyl cysteine 1.2 gm/d (group I ) or placebo (group II) with clomiphene citrate 100mg/d for 5 days. Starting at day 3 of the cycle. Outcome was measured as ovulation rate and pregnancy rate. RESULT – Combination of Clomiphene citrate and N–acetyl cysteine significantly increases both ovulation rate (92.4% Vs 58%) and pregnancy rate (14% Vs 4%). CONCLUSION: – The acetyl cysteine as an adjuvant to Clomiphene citrate was more effective than placebo for patients with PCOS.