COMPARATIVE STUDY OF FENTANYL WITH PROPOFOL AND FENTANYL WITH DEXMEDETOMIDINE AS INTRAVENOUS ANAESTHETICS FOR UPPER GI ENDOSCOPY

Dr.D.V.RAMA SIVA NAIK; Dr.SAYA RAGHAVENDRA PRASAD

Volume : VII, Issue : XI, November - 2017

COMPARATIVE STUDY OF FENTANYL WITH PROPOFOL AND FENTANYL WITH DEXMEDETOMIDINE AS INTRAVENOUS ANAESTHETICS FOR UPPER GI ENDOSCOPY

Dr. D. V. Rama Siva Naik , Dr. Saya Raghavendra Prasad

Abstract :

Background: Upper GI endoscopic procedure requires patient’s cooperation and endoscopist’s satisfaction and this can be improved by intravenous sedation and analgesia.

Aim: to compare the haemodynamic effects and sedation efficacy of fentanyl with propofol and fentanyl with dexmedetomidine in patients undergoing elective diagnostic upper gastrointestinal endoscopy (UGIE).

Material and methods: A total of 60 patients undergoing UGIE were enrolled in the study. Patients were randomly divided into two groups, Group P received 1mg/kg of Propofol followed by 10–20 mg iv bolus when required and group D received an infusion of 1mcg/kg of Dexmedetomidine over 10 min, followed by 0.2–0.7mcg/kg/hr as continuous infusion.

Statistical analysis: Data analysis was done using SPSS version 16.0. p value <0.05 was considered as statistically significant.

Results: Induction time was shorter in propofol group when compared to dexmedetomidine group (0.79 min vs 10.73 min, p=0.0001). Recovery time was early in dexmedetomidine group when compared to propofol group (8.4 min vs 12 min, p=0.0001). Mean arterial pressure was significantly lower in propofol group when compared to dexmedetomidine group. Fall in heart rate was higher in dexmedetomidine when compared to propofol. Respiratory rate, Spo2 and patient satisfaction were comparable in both groups (p > 0.05).

Conclusion: Dexmedetomidine is associated with greater haemodynamic stability and faster recovery when compared to propofol. Endoscopists expressed a higher level of satisfaction with dexmedetomidine compared with propofol.