COMPARATIVE STUDY OF INTRAVENOUS DEXMEDETOMIDINE AND MIDAZOLAM AS A PREOPERATIVE SEDATION UNDER SPINAL ANESTHESIA

Dr. Anisha Chokshi; Dr. Mohan Gandhi; Dr. Sumati Sitpal; Dr. Nirmal Barad; Dr. Ravina Patel

Volume : IX, Issue : VIII, August - 2019

COMPARATIVE STUDY OF INTRAVENOUS DEXMEDETOMIDINE AND MIDAZOLAM AS A PREOPERATIVE SEDATION UNDER SPINAL ANESTHESIA

Dr. Anisha Chokshi, Dr. Mohan Gandhi, Dr. Sumati Sitpal, Dr. Nirmal Barad, Dr. Ravina Patel

Abstract :

INTRODUCTION: Preoperative anxiety is a frequent condition. Comfortable anesthesia induction and maintenance can be achieved by controlling anxiety. Various agents are used to relieve anxiety and provide sedation. We conducted this study to compare the sedative effects of dexmedetomidine versus midazolam for patients undergoing spinal anesthesia. AIMS AND OBJECTIVES : To compare the sedative effect of both drugs and observe intraoperative and postoperative comfort level, cardiovascular and respiratory changes and side effects of both drugs. MATERIALS AND METHODS: Sixty patients between 18–65 years of age requiring spinal anaesthesia for their procedures were selected randomly and division was done in 2 groups (Each group having 30 patients). Group D was given Inj. Dexmedetomidine at the dose of 1 mcg/kg within 10 mins in 100 ml NS and group M was given Inj Midazolam at the dose of 0.04 mg/kg in 100 ml NS within 10 mins. DISCUSSION: Anxiety is more common among young patients, women, and people with negative experience of anesthesia or fear that arises just before the operation and anesthesia my lead to psychological trauma. Various agents such as phenothiazines, bezodiazepines, barbiturates, opioids, propofol, ketamine, dexmedetomidine or clonidine and antihistamines are used to relieve anxiety and provide sedation. Midazolam is a benzodiazepine,commonly used as an intravenous sedative agent for pre–operative sedation. Dexmedetomidine is an alpha–2 agonist which acts on adrenoreceptors in many tissues including the nervous, cardiovascular and respiratory systems. Unlike midazolam, dexmedetomidine does not affect the ventilatory response to carbon dioxide, it also produces analgesia which could potentially alleviate pain.