COMPARATIVE STUDY OF NALBUPHINE AND MORPHINE FOR PAIN RELIEF IN SPINE SURGERIES

Dr. Pabitra Biswas; Dr. Soma Mukhopadhyay; Dr. Chaitali Biswas

Volume : IX, Issue : XII, December - 2019

COMPARATIVE STUDY OF NALBUPHINE AND MORPHINE FOR PAIN RELIEF IN SPINE SURGERIES

Dr. Pabitra Biswas, Dr. Soma Mukhopadhyay, Dr. Chaitali Biswas

Abstract :

Background and aim The aim was to compare the analgesic efficacy of the two drugs nalbuphine and morphine administered intravenously in equi–analgesic doses in patients undergoing open spine surgeries. The primary outcome was the duration of analgesia and the requirement of rescue analgesic. Other than this, the post–operative VAS (visual analogue scale) score and the intraoperative haemodynamic parameters were compared. Methods Eighty patients were selected and were randomly allocated into two groups with forty patients in each. Group M received intravenous morphine 0.15mg per kg of body weight. Group N received nalbuphine 0.15mg per kg of body weight. At the end of operation the VAS score was assessed at regular intervals and when VAS score was more than 4, a rescue analgesic was given. This period between extubation and administration of rescue analgesic was the duration of analgesia. Results Nalbuphine was found to provide a longer duration of analgesia than morphine and it was statistically significant. The VAS scores measured at 30 minutes and 60 minutes showed statistically significant greater value in the morphine group than the nalbuphine group. This meant better post–operative analgesia in patients who received nalbuphine than those who received morphine. Haemodynamic parameters like heart rate, mean arterial pressure were compared and did not show any significant difference in the two groups. No significant side effects like respiratory depression, pruritus, nausea and vomiting were seen during the study. Conclusion The study showed that nalbuphine is a good analgesic and can be used as alternative to morphine in spine surgeries. It is safe and does not cause any significant side effects.