COMPARATIVE STUDY OF TELMISARTAN ALONE AND WITH ATORVASTATIN ON COGNITIVE FUNCTIONS IN MILD TO MODERATE  HYPERTENSIVE  PATIENTS

Kavita Rathore; Dr. Sunil Kumar Mathur

Volume : VI, Issue : IX, September - 2016

COMPARATIVE STUDY OF TELMISARTAN ALONE AND WITH ATORVASTATIN ON COGNITIVE FUNCTIONS IN MILD TO MODERATE HYPERTENSIVE PATIENTS

Kavita Rathore, Dr. Sunil Kumar Mathur

Abstract :

In this study we evaluated the effects of ARB, Telmisartan alone and with Atorvastatin on cognitive functions in hypertensives. Material and Methods : A Prospective, comparative, randomized, beforeafter, open–label study was conducted at a tertiary care hospital of Ajmer. Memory functions were evaluated with PGI Memory Scale, while psychomotor functions were evaluated with Six Letter Cancellation test and Digit Letter Substitution test. Patients ( with SBP≥ 140 mm hg; DBP ≥ 90 mm Hg) devided into two groups, group I (n=52) received Telmisartan 40 mg OD and group II (n=51) received Telmisartan 40 mg OD with Atorvastatin 10 mg OD for 16 weeks. Wilcoxon Signed Rank test and Mann Whitney U test were used. Statistical significance was considered at P<0.05. Results : A improvement in scores of memory and psychomotor functions were observed in both the groups. A statistically significant difference (p<0.05) in both groups was shown in 2 subtests out of 10 subtests of memory functions. Both the groups showed significant improvement in psychomotor function tests (p<0.05). Conclusion :Telmisartan shows improvement in cognitive functions in both groups. Atorvastatin did not affect memory and psychomotor functions adversely.