Comparative study of the efficacy of ormeloxifene, danazol and evening primrose oil on treatment of breast nodularity

Noopur Mishra; Priya Singh

Volume : X, Issue : IV, April - 2020

Comparative study of the efficacy of ormeloxifene, danazol and evening primrose oil on treatment of breast nodularity

Noopur Mishra, Priya Singh

Abstract :

Introduction: Mastalgia is a common problem and 60–70% women encounter it at least once in their lifetime. Manydrugs have been used and are been used with varying response, like Tamoxifen, Danazol, primrose oil, topical analgesics and recently Centchroman. This study was undertaken to compare the clinical efficacy of ormeloxifene, danazol and evening primrose oil and treatment response on east nodularity with help of Lucknow– Cardiff scale. Materials and Methods:The present study was carried out on approximately 100 women attending out–patient and in–patient service of department of Obstetrics and Gynecology at Swaroop Rani Nehru Hospital, Allahabad and Kamla Nehru Memorial Hospital, Allahabad, of Moti Lal Nehru Medical College, Allahabad over a period from August 2014 to July2015.Written informed consent was obtained from these women after explaining in detail about the study.The distribution of patient characteristics was expressed as frequencies and percentage. All statistical analysis was done using Microsoft excel. Results:Maximum numbers of cases (71.8%) were of age group of 21 to 30 years. The mean age of cases of ormeloxifene group was 26.96±5.257 years, mean age of danazol group was 26.81±5.497 years and mean age of evening primrose oil group was 27±5.345 years.In all the three groups, one half of patients had grade–4, grade–5 of east nodularity, in ormeloxifene group 50%, in danazol group 50% and in evening primrose oil group 46.14% cases had grade–4 and grade–5 nodularity. Conclusion: Ormeloxifene was found to be superior to danazol in treating mastalgia and danazol was found to be superior to evening primrose oil for management of mastalgia.