COMPARISION OF ANALGESIC EFFECT OF ORAL 25% DEXTROSE, 12% SUCROSE,24% SUCROSE  AND PLACEBO DURING 1 ST DPT VACCINATION IN HEALTHY TERM INFANTS

Saiprasad kavthekar; Hemant bharti; Anil kurne

Volume : VI, Issue : V, May - 2016

COMPARISION OF ANALGESIC EFFECT OF ORAL 25% DEXTROSE, 12% SUCROSE,24% SUCROSE AND PLACEBO DURING 1 ST DPT VACCINATION IN HEALTHY TERM INFANTS

Saiprasad Kavthekar, Hemant Bharti, Anil Kurne

Abstract :

 Objective: To compare analgesic effect of 12% sucrose, 25% dextrose, 24% sucrose and placebo during 1st DPT vaccination in healthy term infants. Design: Double blind, randomized placebo controlled trial. Setting: Immunization clinic of Department of Paediatrics, Dr. D.Y Patil Medical College, Kolhapur Participants: Infants coming for their 1 st DPT vaccination were randomized in to four groups of 50 each. Interventions: Infants in interventional group received sterile water, 12% sucrose, 25% dextrose, 24% sucrose. Outcome measures: The primary outcome variables was the duration of cry after vaccination. Secondary outcome variables were change in heart rate from base line and change in behavioural state score according to Glad man at three minutes after vaccination. Result: Mean total duration of cry was significantly lower in 24% sucrose fed babies36.3(25.34) seconds, 25% dextrose fed babies 67.1(38.53) seconds and 12% sucrose fed babies 101.11(34.13) seconds as compared to babies given sterile water 137.2(20.31)seconds. Mean rise in heart rate(beats/min) at 3 minutes after vaccination was significantly lower with 24% sucrose 3(2.3), 25% dextrose (5.6), 12% sucrose 13.4(4.6)as compared to sterile water 18.2(4.61). There was no rise in behvioural state score only with 24% sucrose fed babies. Conclusion: 24% sucrose has better analgesic activity than 25% dextrose in infants less than 2 months of age undergoing DPT vaccination.